About this blog

CRIT is no longer adding posts or updating the CRITical Thinking blog.

CRITical Thinking is a blog written by staff, directors, and friends of the Collaboration for Research Integrity and Transparency (CRIT), a joint program of Yale Law School, Yale School of Public Health, and Yale School of Medicine. CRIT's mission is to promote health by improving the integrity and transparency of biomedical and clinical research.

This blog is published by and reflects the personal views of the individual authors, in their individual capacities. It does not purport to represent Yale University's institutional views, if any. No representation is made about the accuracy of the information, which solely constitutes the authors’ personal views on issues discussed. The information contained in this blog is provided only as general information and personal opinions, and blog topics may be updated after being initially posted.

 

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transparency
market exclusivity
Pharmaceutical Marketing
right to try
EMA
data sharing
lifecycle evaluation
reproducibility
YaleCRIT17
payers
patient advocacy
meta-research
trials
medical evidence
research integrity
regulatory approval
FDA
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CRITical Thinking Blog

Seven Thoughts on the History and Present Practices of the FDA and Uses of Prescription Drugs

January 31, 2018
By Donald W. Light, Joel Lexchin

From before 1906, when the Pure Food and Drugs Act was passed, through the Vioxx crisis in 2004 to today, organized pharmaceutical lobbying has consistently tried to undermine Congressional efforts to protect patients from unsafe and ineffective drugs, often with considerable success.

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Transparency By Sleight of Hand?

January 3, 2018
By Matthew Herder

Members of the modern pharmaceutical industry were once known as “ethical manufacturers” because they eschewed the secrecy and quackery of their “proprietary medicine” predecessors.

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New Study Documents Harm Caused by Evidence Distortion in Medical Research

December 18, 2017
By Margaret McCarthy

Four health integrity organizations have come together to call on governments to ensure that patients, doctors, and scientists can access the full results of all clinical trials.

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Promoting Transparency in Clinical Research

November 3, 2017
By Margaret McCarthy, Jeanie Kim, Joseph S. Ross

Clinical research generates information that is critical to our understanding of medical products. Researchers and pharmaceutical companies conduct clinical studies to see if a promising biomedical discovery can lead to a safe and effective medicine for patients. Investigators start with laboratory testing and preclinical studies that provide basic answers about a treatment’s mechanism. Then, studies involving human participants provide a clearer picture of how the drug, biologic, or device will interact with the human body: Is the drug toxic or safe to use? What is the appropriate dosage?

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